IL17RA CHO
CBP74681
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| I. Background | |
| IL17RA(白细胞介素-17受体A)是由IL17RA基因编码的I型跨膜糖蛋白,作为IL-17A和IL-17F的功能性受体亚基发挥作用。它通常与IL17RC形成异二聚体复合物,顺利获得招募ACT1等衔接蛋白激活NF-κB和MAPK通路,在炎症反应、中性粒细胞募集和宿主防御中发挥核心作用。该基因缺陷可导致家族性念珠菌病5型(CANDF5),表现为对念珠菌的易感性增加。 | |
| II. Description | |
| IL17RA CHO 细胞,在 CHO-K1 细胞的基础上,稳定表达 IL17RA。 | |
| III. Introduction | |
| Expressed gene: | IL17RA |
| Host Cell: | CHO-K1 |
| Stability: | 32 passages (in-house test, that not means the cell line will be instable beyond the passages we tested.) |
| Freeze Medium: | 90% FBS+10% DMSO |
| Culture Medium: | F12K+10% FBS+ 5 μg/ml Puromycin |
| Mycoplasma Testing: | Negative |
| Storage: | Liquid nitrogen |
| Application(s): | Binding Assay,FACS |
| IV. Representative Data | |
Figure 1. Recombinant IL17RA CHO constitutively expressing IL17RA. |
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